segmentation clock
| PAG Title | segmentation clock |
| PAG ID | WAG000420 |
| Type | P |
| Source Link |  BioCarta |
| Publication Reference | NA |
| PAG Description | In most animal species, the anteroposterior body axis is generated by the formation of repeated structures called segments. In vertebrate segmentation, a specialized mesodermal structure called the somite gives rise to sceletal muscles, vertebrae, and some dermis. Formation of the somites is a rhythmic process that involves an oscillator - the segmentation clock - driven by Wnt and Notch sigling. The clock ticks in somite precursors and halts when they reach a specific maturation stage defined as the wavefront, established by FGF and Wnt sigling.. Here we present the expression sequence of Lutic fringe and axin mRs during the formation of the two somites. The Lutic fringe was shown to act downstream of Notch and to bind and negatively regulate its own promoter. Another cyclic gene is hes1. It acts also downstream of Notch and codes for an unstable protein able to negatively regulate its own promoter too. |
| Species | Homo sapiens |
| nCoCo Score | 773 |
| Base PAG ID | WAG000420 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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